Urease
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Importance
Urease is important because of its role in the Nitrogen cycle as a key catalyst in the reaction converting urea to ammonium and CO2. Urease occurs as a soil enzyme, likely because soil microorganisms benefit from the nitrogen made available by urea degradation in the form of ammonium.cite-ref-7[7]
Structure
A 1984 study focusing on urease from jack bean found that the active site contains a pair of nickel centers.cite-ref-8[8] In vitro activation also has been achieved with manganese and cobalt in place of nickel.cite-ref-pmid20046957-9-0[9] Lead salts are inhibiting.
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